Microencapsulation of a synbiotic into PLGA / alginate
نویسندگان
چکیده
Michael T. Cook, George Tzortzis, Dimitris Charalampopoulos*, Vitaliy V. Khutoryanskiy* 4 School of Pharmacy, University of Reading, Reading, RG6 6AD, United Kingdom 5 Clasado Research Services Ltd, Science and Technology Centre, University of Reading, Earley 6 Gate, Whiteknights Road, Reading, RG6 6BZ, United Kingdom 7 Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AD, 8 United Kingdom 9
منابع مشابه
The Production of Synbiotic Bread by Microencapsulation.
Bread is a global staple food. Despite attempts to develop functional breads containing viable microorganisms, this has not been done yet because of the high temperature during baking. The aim of this study is to obtain synbiotic bread, hence hamburger bun and white pan bread were selected. Lactobacillus acidophilus LA-5 and L. casei 431 were encapsulated with calcium alginate and Hi-maize resi...
متن کاملBioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading
Poly(lactic-co-glycolic acid) (PLGA) is the most widely used biomaterial for microencapsulation and prolonged delivery of therapeutic drugs, proteins and antigens. PLGA has excellent biodegradability and biocompatibility and is generally recognized as safe by international regulatory agencies including the United States Food and Drug Administration and the European Medicines Agency. The physico...
متن کاملrhEGF-loaded PLGA-Alginate microspheres enhance the healing of full-thickness excisional wounds in diabetised Wistar rats.
Diabetic foot ulcers (DFUs) represent a major clinical challenge in the ageing population. To address this problem, rhEGF-loaded Poly-Lactic-co-Glycolic-Acid (PLGA)-Alginate microspheres (MS) were prepared by a modified w/o/w-double-emulsion/solvent evaporation method. Different formulations were evaluated with the aim of optimising MSs properties by adding NaCl to the surfactant solution and/o...
متن کاملSustained Release of Risedronate from PLGA Microparticles Embedded in Alginate Hydrogel for Treatment of Bony Lesions
Background: Inflammatory bone resorption in periodontitis can lead to tooth loss. Systemic administration of bisphosphonates such as risedronate for preventing bone resorption can cause adverse effects. Alginate hydrogel (ALG) and poly (lactic acid-co-glycolic acid) (PLGA) microparticles have been studied as drug delivery systems for sustained release of drugs. Therefore, the release pattern of...
متن کاملFluidised Bed Microencapsulation of Ascorbic Acid: Effectiveness of Protection under Simulated Tropical Storage Conditions
This study investigates the use of microencapsulation by fluidised bed coating for the protection of ascorbic acid during long-term storage under simulated tropical conditions. Microencapsulation materials, loading levels, fluidised bed processing conditions and the results of storage trials were evaluated. Cellets® 350 is a suitable base material, whereas sugar spheres are not suitable due to ...
متن کامل